Define what is unknown.
It can arise from
News Stories
Personal Experiences
Review of Research
Electronic Databases
Library Indexes - National Library of Medcine
Web pages
Medical Authorities
Opinion Leaders
Funding Sources
State the pertinence and significance of the question and how the research can answer it.
Reference:http://www.ruf.rice.edu/~bioslabs/tools/report/reportform.html
https://catalyst.harvard.edu/training_fellowships_matrix.html